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High risk factors for pulmonary fungous infection in intensive care units of neurosurgery
ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing
Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 299-303 doi: 10.1007/s11684-007-0057-8
Keywords: seventeen incidence glucocorticoid broad-spectrum antibiotic Candidiasis
Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants
Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz
Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 5, doi: 10.1007/s11783-020-1268-3
Keywords: Zero-Valent Iron (ZVI) Oxidants Heavy Metals (HMs) Metalloids Nitrate Phosphate
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
Engineering 2024, Volume 32, Issue 1, Pages 42-57 doi: 10.1016/j.eng.2023.08.001
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.
Keywords: COBRA Influenza A Salmonella Vaccine Broad spectral protection
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1120-9
Reviewed the change of ARGs and ARB in full-scale urban drinking water systems. Conventional processes are more promising than BAC process in ARGs removal. Mechanisms of ARGs enrichment and spread in BAC filter and DWDSs are discussed. Raise the need of future research on ARGs and ARB change in building plumbing systems.
Keywords: Antibiotic resistant bacteria Antibiotic resistance genes Water source Drinking water treatment plant
Mirror system based therapy for autism spectrum disorders
CHEN Wei, ZHANG Jing, DING Jun
Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 344-347 doi: 10.1007/s11684-008-0065-3
Keywords: emotional cognition observation activation spectrum empirical research
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1469-4
• Distribution of ARGs in decentralized sewage facilities were investigated.
Keywords: Decentralized sewage treatment facilities Antibiotic resistance genes Virus Metagenomics Network
Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions
Xin Yu, Virender K. Sharma, Hui Li
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1137-0
The antibiotic resistome: gene flow in environments, animals and human beings
Yongfei Hu, George F. Gao, Baoli Zhu
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 161-168 doi: 10.1007/s11684-017-0531-x
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics.Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide rangeHowever, the antibiotic selection pressure conferred by the use of antibiotics in both human medicineand agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulationemphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic
Keywords: antibiotic resistance resistome microbiome gene flow
Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review
Sanli TANG, Jie SUN, Hui HONG, Qibin LIU
Frontiers in Energy 2017, Volume 11, Issue 4, Pages 437-451 doi: 10.1007/s11708-017-0509-z
Keywords: photo-thermal catalysis spectrum-selectivity solar fuel full-spectrum
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
Keywords: Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,
Engineering doi: 10.1016/j.eng.2023.04.015
Keywords: Knowledge sharing Internet of Vehicles Federated learning Broad learning Reconfigurable intelligent surfaces
Analysis of antibiotic resistance of
Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1123-6
There was a seasonal difference in antibioticlistitem> The E. coli in the Yitong River was found to have multiple antibiotic
Keywords: Yitong River Coliform bacteria Antibiotic resistance Escherichia coli
MA Xiaoyan, CHEN Beibei, LI Qingsong, ZHANG Qiaoli, GU Guofen
Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3, Pages 286-291 doi: 10.1007/s11783-007-0048-7
Keywords: summer flocculation simple Shanghai spectrum
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 693-703 doi: 10.1007/s11684-020-0777-6
Keywords: S. typhi antibiotic resistance mechanism resistome identification methods
Qingkun Ji, Caihong Zhang, Dan Li
Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 6, doi: 10.1007/s11783-020-1287-0
Keywords: Nanofullerene Sub-minimum inhibitory concentrations Antibiotic resistance genes Conjugation Molecular
Title Author Date Type Operation
High risk factors for pulmonary fungous infection in intensive care units of neurosurgery
ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing
Journal Article
Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants
Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz
Journal Article
Salmonella-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
Journal Article
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
Journal Article
Mirror system based therapy for autism spectrum disorders
CHEN Wei, ZHANG Jing, DING Jun
Journal Article
Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized
Journal Article
Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions
Xin Yu, Virender K. Sharma, Hui Li
Journal Article
The antibiotic resistome: gene flow in environments, animals and human beings
Yongfei Hu, George F. Gao, Baoli Zhu
Journal Article
Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review
Sanli TANG, Jie SUN, Hui HONG, Qibin LIU
Journal Article
Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
Journal Article
Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of
Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,
Journal Article
Analysis of antibiotic resistance of
Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan
Journal Article
Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum(LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)
MA Xiaoyan, CHEN Beibei, LI Qingsong, ZHANG Qiaoli, GU Guofen
Journal Article
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
Journal Article